Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids.Previously, we reported on the use of the RBM14 fluorogenic ceramide analogs to determine acidic ceramidase activity.In this work, we investigated the activity of other amidohydrolases on RBM14 compounds.Both bacterial and human purified neutral ceramidases (NCs), as Yo
Abstract Studying comorbidities in patients with psoriatic arthritis (PsA) provides a better understanding of the extended burden of the disease.Depression and anxiety are well recognized but understudied comorbidities in patients with PsA.The prevalence of depression is significantly higher in this patient population than in the general population
Increasingly more people cycle with electrically-powered pedal assistance.The reduced pedalling effort attracts physically challenged people and seniors, who have a higher risk of falling.Since electric bicycles are heavier and the centre of masses are located higher, accidents happen easily.This study analyses the influence of the addition of a ba
The Bacillus subtilis GlmR (formerly YvcK) protein is essential for growth on gluconeogenic carbon sources.Mutants lacking GlmR display a variety of phenotypes suggestive of impaired cell wall synthesis including antibiotic sensitivity, aberrant cell morphology and lysis.To define the role of GlmR, we selected suppressor mutations that ameliorate t